The easiest way to go about seeing if you have the problem is to cat the /proc/interrupts file.
[blog@web ~]$ cat /proc/interrupts
CPU0 CPU1 CPU2 CPU3
0: 165886477 0 0 0 IO-APIC-edge timer
1: 3 0 0 0 IO-APIC-edge i8042
8: 0 0 0 0 IO-APIC-edge rtc
9: 0 0 0 0 IO-APIC-level acpi
12: 4 0 0 0 IO-APIC-edge i8042
50: 0 0 0 0 IO-APIC-level sata_nv
58: 0 0 0 0 IO-APIC-level sata_nv
82: 210 0 0 107566 PCI-MSI eth0
90: 49 0 100834 0 PCI-MSI eth1
So you are asking now what are you to be looking for, well check out the eth0 and eth1 lines. As you can see this is a 4 Core box and has all the interrupts for eth0 running on CPU3 and eth1 on CPU2. This box is not in production so the numbers are small but still shows a problem. Following post will suggest fixes to this problem and the fix that I took.